![]() Some users say the combination, dubbed "tranq" or "tranq dope," gives a longer-lasting high, more like heroin, which has largely been replaced by fentanyl in U.S. In almost all cases, xylazine-a drug for sedating horses and other animals-is added to fentanyl, the potent opioid that can be lethal even in small amounts. "All we know is that there are a lot of people taking xylazine and a lot of them are dying, but it doesn't mean that xylazine is doing it." Lewis Nelson of Rutgers New Jersey Medical School, who advises federal regulators on drug safety. "We don't know whether xylazine is increasing the risk of overdose or reducing the risk of overdose," said Dr. There is broad agreement, however, that much more information is needed to understand xylazine's impact, to craft ways of disrupting illegal supplies and to develop medicines to reverse its effects. In fact, early data suggests the drug may inadvertently be diluting the effects of fentanyl, the synthetic opioid behind most overdose deaths. ![]() Xylazine can cause severe skin wounds, but whether it is leading to more deaths-as suggested by officials in Washington-is not yet clear, according to health and law enforcement professionals on the front lines of efforts in New Jersey, New York and Pennsylvania.
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